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History of cerebrovascular disease but not dementia increases the risk for secondary vascular events during SARS-CoV-2 infection with presumed Omicron variant: a retrospective observational study.
Mayer, Christina; Woo, Marcel S; Brehm, Thomas Theo; Heyer, Andreas; Fischer, Marlene; Fischbach, Felix; Bal, Lukas C; Addo, Marylyn M; Kluge, Stefan; Thomalla, Götz; Schweingruber, Nils; Schulze Zur Wiesch, Julian.
Afiliación
  • Mayer C; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Woo MS; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Brehm TT; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Heyer A; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Fischer M; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Fischbach F; German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
  • Bal LC; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Addo MM; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Kluge S; Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Thomalla G; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schweingruber N; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schulze Zur Wiesch J; I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Eur J Neurol ; 30(8): 2297-2304, 2023 08.
Article en En | MEDLINE | ID: mdl-37159495
BACKGROUND AND PURPOSE: This study aimed to investigate if pre-existing neurological conditions, such as dementia and a history of cerebrovascular disease, increase the risk of severe outcomes including death, intensive care unit (ICU) admission and vascular events in patients hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in 2022, when Omicron was the predominant variant. METHODS: A retrospective analysis was conducted of all patients with SARS-CoV-2 infection, confirmed by polymerase chain reaction test, admitted to the University Medical Center Hamburg-Eppendorf from 20 December 2021 until 15 August 2022. In all, 1249 patients were included in the study. In-hospital mortality was 3.8% and the ICU admission rate was 9.9%. Ninety-three patients with chronic cerebrovascular disease and 36 patients with pre-existing all-cause dementia were identified and propensity score matching by age, sex, comorbidities, vaccination status and dexamethasone treatment was performed in a 1:4 ratio with patients without the respective precondition using nearest neighbor matching. RESULTS: Analysis revealed that neither pre-existing cerebrovascular disease nor all-cause dementia increased mortality or the risk for ICU admission. All-cause dementia in the medical history also had no effect on vascular complications under investigation. In contrast, an increased odds ratio for both pulmonary artery embolism and secondary cerebrovascular events was observed in patients with pre-existing chronic cerebrovascular disease and myocardial infarction in the medical history. CONCLUSION: These findings suggest that patients with pre-existing cerebrovascular disease and myocardial infarction in their medical history may be particularly susceptible to vascular complications following SARS-CoV-2 infection with presumed Omicron variant.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastornos Cerebrovasculares / COVID-19 / Infarto del Miocardio Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastornos Cerebrovasculares / COVID-19 / Infarto del Miocardio Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Alemania