Your browser doesn't support javascript.
loading
Consensus Recommendations to Optimize the Detection and Reporting of NTRK Gene Fusions by RNA-Based Next-Generation Sequencing.
Stockley, Tracy L; Lo, Bryan; Box, Adrian; Gomez Corredor, Andrea; DeCoteau, John; Desmeules, Patrice; Feilotter, Harriet; Grafodatskaya, Daria; Hawkins, Cynthia; Huang, Weei Yuarn; Izevbaye, Iyare; Lepine, Guylaine; Papadakis, Andreas I; Park, Paul C; Sheffield, Brandon S; Tran-Thanh, Danh; Yip, Stephen; Sound Tsao, Ming.
Afiliación
  • Stockley TL; Laboratory Medicine Program, University Health Network, Toronto, ON M5G 2C4, Canada.
  • Lo B; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5R 0A3, Canada.
  • Box A; Advanced Molecular Diagnostics Laboratory, Princess Margaret Cancer Centre, Toronto, ON M5G 2C1, Canada.
  • Gomez Corredor A; Department of Pathology and Laboratory Medicine, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
  • DeCoteau J; Alberta Precision Laboratories, Calgary, AB T2N 7A4, Canada.
  • Desmeules P; McGill University Health Center, Montreal, QC H4A 3J1, Canada.
  • Feilotter H; Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5A9, Canada.
  • Grafodatskaya D; IUCPQ-UL, Quebec Heart and Lung Institute, Quebec City, QC G1V 4G5, Canada.
  • Hawkins C; Kingston Health Sciences Centre, Kingston, ON K7L 2V7, Canada.
  • Huang WY; Department of Pathology and Molecular Medicine, Queens University, Kingston, ON K7L 3N6, Canada.
  • Izevbaye I; Hamilton Health Sciences Centre, Hamilton, ON L9C 1C4, Canada.
  • Lepine G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8S 4K1, Canada.
  • Papadakis AI; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5R 0A3, Canada.
  • Park PC; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
  • Sheffield BS; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5R 0A3, Canada.
  • Tran-Thanh D; Nova Scotia Health Authority, Halifax, NS B3H 2E2, Canada.
  • Yip S; Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada.
  • Sound Tsao M; Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R7, Canada.
Curr Oncol ; 30(4): 3989-3997, 2023 03 31.
Article en En | MEDLINE | ID: mdl-37185415
The detection of gene fusions by RNA-based next-generation sequencing (NGS) is an emerging method in clinical genetic laboratories for oncology biomarker testing to direct targeted therapy selections. A recent Canadian study (CANTRK study) comparing the detection of NTRK gene fusions on different NGS assays to determine subjects' eligibility for tyrosine kinase TRK inhibitor therapy identified the need for recommendations for best practices for laboratory testing to optimize RNA-based NGS gene fusion detection. To develop consensus recommendations, representatives from 17 Canadian genetic laboratories participated in working group discussions and the completion of survey questions about RNA-based NGS. Consensus recommendations are presented for pre-analytic, analytic and reporting aspects of gene fusion detection by RNA-based NGS.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptor trkA / Neoplasias Tipo de estudio: Diagnostic_studies / Guideline Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Curr Oncol Año: 2023 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Receptor trkA / Neoplasias Tipo de estudio: Diagnostic_studies / Guideline Límite: Humans País/Región como asunto: America do norte Idioma: En Revista: Curr Oncol Año: 2023 Tipo del documento: Article País de afiliación: Canadá