Mpox Knowledge Graph: a comprehensive representation embedding chemical entities and associated biology of Mpox.
Bioinform Adv
; 3(1): vbad045, 2023.
Article
en En
| MEDLINE
| ID: mdl-37187795
ABSTRACT
Summary:
The outbreak of Mpox virus (MPXV) infection in May 2022 is declared a global health emergency by WHO. A total of 84 330 cases have been confirmed as of 5 January 2023 and the numbers are on the rise. The MPXV pathophysiology and its underlying mechanisms are unfortunately not yet understood. Likewise, the knowledge of biochemicals and drugs used against MPXV and their downstream effects is sparse. In this work, using Knowledge Graph (KG) representations we have depicted chemical and biological aspects of MPXV. To achieve this, we have collected and rationally assembled several biological study results, assays, drug candidates and pre-clinical evidence to form a dynamic and comprehensive network. The KG is compliant with FAIR annotations allowing seamless transformation and integration to/with other formats and infrastructures. Availability and implementation The programmatic scripts for Mpox KG are publicly available at https//github.com/Fraunhofer-ITMP/mpox-kg. It is hosted publicly at https//doi.org/10.18119/N9SG7D. Supplementary information Supplementary data are available at Bioinformatics Advances online.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Bioinform Adv
Año:
2023
Tipo del documento:
Article
País de afiliación:
Alemania