Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF-&#954;B signaling pathway activation in aged mice.

Yao, Yusheng; Lin, Daoyi; Chen, Yuzhi; Liu, Linwei; Wu, Yushang; Zheng, Xiaochun

Fluoxetine alleviates postoperative cognitive dysfunction by attenuating TLR4/MyD88/NF-κB signaling pathway activation in aged mice.

Yao, Yusheng; Lin, Daoyi; Chen, Yuzhi; Liu, Linwei; Wu, Yushang; Zheng, Xiaochun.

Afiliación

Yao Y; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134, Dongjie, Fuzhou, 350001, Fujian, China.
Lin D; Fujian Provincial Key Laboratory of Critical Care Medicine, Fuzhou, Fujian, China.
Chen Y; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134, Dongjie, Fuzhou, 350001, Fujian, China.
Liu L; Clinical Medical College, Fujian Medical University, Fuzhou, Fujian, China.
Wu Y; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134, Dongjie, Fuzhou, 350001, Fujian, China.
Zheng X; Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134, Dongjie, Fuzhou, 350001, Fujian, China.

Inflamm Res ; 72(6): 1161-1173, 2023 Jun.

Article en En | MEDLINE | ID: mdl-37188940

Asunto(s)

FN-kappa B; Complicaciones Cognitivas Postoperatorias; Ratones; Masculino; Animales; FN-kappa B/metabolismo; Complicaciones Cognitivas Postoperatorias/metabolismo; Factor 88 de Diferenciación Mieloide/metabolismo; Fluoxetina/farmacología; Fluoxetina/uso terapéutico; Fluoxetina/metabolismo; Receptor Toll-Like 4/metabolismo; Enfermedades Neuroinflamatorias; Ratones Endogámicos C57BL; Transducción de Señal; Citocinas/metabolismo; Microglía/metabolismo

Palabras clave

Fluoxetine; Microglia; Neuroinflammation; Postoperative cognitive dysfunction; Toll-like receptor 4

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: FN-kappa B / Complicaciones Cognitivas Postoperatorias Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Inflamm Res Asunto de la revista: ALERGIA E IMUNOLOGIA / PATOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China

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