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Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice.
Liu, Li; Liu, Biting; Wang, Lian; Li, Caixia; Zhou, Yang; Zhu, Jihui; Ding, Jinye; Liu, Shupeng; Cheng, Zhongping.
Afiliación
  • Liu L; Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
  • Liu B; Institute of Gynecological Minimally Invasive Medicine, School of Medicine, Tongji University, Shanghai, 200072, China.
  • Wang L; Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
  • Li C; Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
  • Zhou Y; Institute of Gynecological Minimally Invasive Medicine, School of Medicine, Tongji University, Shanghai, 200072, China.
  • Zhu J; Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
  • Ding J; Institute of Gynecological Minimally Invasive Medicine, School of Medicine, Tongji University, Shanghai, 200072, China.
  • Liu S; Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
  • Cheng Z; Institute of Gynecological Minimally Invasive Medicine, School of Medicine, Tongji University, Shanghai, 200072, China.
Reprod Biol Endocrinol ; 21(1): 46, 2023 May 16.
Article en En | MEDLINE | ID: mdl-37194006
Efficient evaluation of the primordial follicle pool (PFP) of mammalian models is an essential subject in biomedical research relating to ovarian physiology and pathogenesis. Our recent study has identified a gene signature including Sohlh1, Nobox, Lhx8, Tbpl2, Stk31, Padi6, and Vrtn strongly correlated with ovarian reserve by using bioinformatics analysis. Aimed to investigate the validity of these candidate biomarkers for evaluating the PFP, we utilized an OR comparison model to decode the relationship between the numbers of PFP and candidate biomarkers in the present study. Our results suggest that these biomarkers Sohlh1, Nobox, Lhx8, Tbpl2, Stk31, Padi6, and Vrtn possess independent potential to evaluate the number of the PFP. And the combination of Sohlh1 and Lhx8 can be used as the optimal biomarkers for rapid assessment of the PFP in the murine ovary. Our findings provide a new perspective for evaluating the PFP of the ovary in animal studies and the clinic.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Folículo Ovárico Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Reprod Biol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / MEDICINA REPRODUTIVA Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Folículo Ovárico Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Reprod Biol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / MEDICINA REPRODUTIVA Año: 2023 Tipo del documento: Article País de afiliación: China