Comparisons between human and rodent hepatic glutathione S-Transferase activities reveal sex and species differences.

Doerksen, Michael J; Seo, Denny; Smith, Alexander D; Jones, Robert S; Coughtrie, Michael W H; Collier, Abby C

Doerksen, Michael J; Seo, Denny; Smith, Alexander D; Jones, Robert S; Coughtrie, Michael W H; Collier, Abby C.

Afiliación

Doerksen MJ; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
Seo D; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
Smith AD; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
Jones RS; Genentech Inc, South San Francisco, CA, USA.
Coughtrie MWH; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.
Collier AC; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada.

Xenobiotica ; 53(4): 223-230, 2023 Apr.

Article en En | MEDLINE | ID: mdl-37194558

Asunto(s)

Glutatión Transferasa; Roedores; Masculino; Femenino; Humanos; Ratas; Ratones; Animales; Roedores/metabolismo; Especificidad de la Especie; Glutatión Transferasa/metabolismo; Hígado/metabolismo; Glutatión

Palabras clave

Animal species conjugation drug metabolism glutathione S-transferases in-vitro-in vivo extrapolation risk prediction toxicology

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Roedores / Glutatión Transferasa Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Xenobiotica Año: 2023 Tipo del documento: Article País de afiliación: Canadá

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