Preimplantation genetic testing for mitochondrial DNA mutation: ovarian response to stimulation, outcomes and follow-up.
Reprod Biomed Online
; 47(1): 61-69, 2023 07.
Article
en En
| MEDLINE
| ID: mdl-37202317
ABSTRACT
RESEARCH QUESTION How do carriers of pathogenic mitochondrial DNA (mtDNA) respond to ovarian stimulation? DESIGN:
A single-centre, retrospective study conducted between January 2006 and July 2021 in France. Ovarian reserve markers and ovarian stimulation cycle outcomes were compared for couples undergoing preimplantation genetic testing (PGT) for maternally inherited mtDNA disease (nâ¯=â¯18) (mtDNA-PGT group) with a matched-control group of patients undergoing PGT for male indications (nâ¯=â¯96). The PGT outcomes for the mtDNA-PGT group and the follow-up of these patients in case of unsuccessful PGT was also reported.RESULTS:
For carriers of pathogenic mtDNA, parameters of ovarian response to FSH and ovarian stimulation cycle outcomes were not different from those of matched-control ovarian stimulation cycles. The carriers of pathogenic mtDNA needed a longer ovarian stimulation and higher dose of gonadotrophins. Three patients (16.7%) obtained a live birth after the PGT process, and eight patients (44.4%) achieved parenthood through alternativemethods:
oocyte donation (nâ¯=â¯4), natural conception with prenatal diagnosis (nâ¯=â¯2) and adoption (nâ¯=â¯2).CONCLUSION:
To the best of our knowledge, this is the first study of women carrying a mtDNA variant who have undergone a PGT for monogenic (single gene defects) procedure. It is one of the possible options to obtain a healthy baby without observing an impairment in ovarian response to stimulation.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fertilización In Vitro
/
Diagnóstico Preimplantación
Tipo de estudio:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
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Pregnancy
Idioma:
En
Revista:
Reprod Biomed Online
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
2023
Tipo del documento:
Article