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Responsiveness to Vedolizumab Therapy in Ulcerative Colitis is Associated With Alterations in Immune Cell-Cell Communications.
Hsu, Paul; Choi, Eunice J; Patel, Shefali A; Wong, William H; Olvera, Jocelyn G; Yao, Priscilla; Liu, Yi Chia; Tsai, Matthew S; Wang, Wei; Boland, Brigid S; Chang, John T.
Afiliación
  • Hsu P; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Choi EJ; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA.
  • Patel SA; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Wong WH; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Olvera JG; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Yao P; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Liu YC; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Tsai MS; Department of Medicine, University of California San Diego, La Jolla, California, USA.
  • Wang W; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, USA.
  • Boland BS; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, USA.
  • Chang JT; Department of Medicine, University of California San Diego, La Jolla, California, USA.
Inflamm Bowel Dis ; 29(10): 1602-1612, 2023 10 03.
Article en En | MEDLINE | ID: mdl-37235748
Compared to ulcerative patients unresponsive to vedolizumab, immune cell networks of ulcerative colitis patients responsive to vedolizumab have decreased proportion of TH17 and less pro-inflammatory signaling in the gut. Decreased pro-TH17 and interleukin (IL)-1 signaling from classical monocytes and innate immunocytes may mediate this phenotype.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis Ulcerosa Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Inflamm Bowel Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Enfermedades Inflamatorias del Intestino / Colitis Ulcerosa Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Inflamm Bowel Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos