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NMT1 sustains ICAM-1 to modulate adhesion and migration of tumor cells.
Wang, Hong; Xu, Xin; Wang, Yikun; Xue, Xiangfei; Guo, Wanxin; Guo, Susu; Qiu, Shiyu; Cui, Jiangtao; Qiao, Yongxia.
Afiliación
  • Wang H; School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
  • Xu X; Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 200030, China.
  • Wang Y; Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 200030, China.
  • Xue X; Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 200030, China.
  • Guo W; Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 200030, China.
  • Guo S; Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 200030, China.
  • Qiu S; Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 200030, China.
  • Cui J; Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, 200030, China.
  • Qiao Y; School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, 200030, China. Electronic address: yongxia.qiao@shsmu.edu.cn.
Cell Signal ; 109: 110739, 2023 09.
Article en En | MEDLINE | ID: mdl-37269961
Protein modifications have significant effects on tumorigenesis. N-Myristoylation is one of the most important lipidation modifications, and N-myristoyltransferase 1 (NMT1) is the main enzyme required for this process. However, the mechanism underlying how NMT1 modulates tumorigenesis remains largely unclear. Here, we found that NMT1 sustains cell adhesion and suppresses tumor cell migration. Intracellular adhesion molecule 1 (ICAM-1) was a potential functional downstream effector of NMT1, and its N-terminus could be N-myristoylated. NMT1 prevented ubiquitination and proteasome degradation of ICAM-1 by inhibiting Ub E3 ligase F-box protein 4, which prolonged the half-life of ICAM-1 protein. Correlations between NMT1 and ICAM-1 were observed in liver and lung cancers, which were associated with metastasis and overall survival. Therefore, carefully designed strategies focusing on NMT1 and its downstream effectors might be helpful to treat tumors.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aciltransferasas / Molécula 1 de Adhesión Intercelular Límite: Humans Idioma: En Revista: Cell Signal Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aciltransferasas / Molécula 1 de Adhesión Intercelular Límite: Humans Idioma: En Revista: Cell Signal Año: 2023 Tipo del documento: Article País de afiliación: China