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The Utility of ctDNA in Lung Cancer Clinical Research and Practice: A Systematic Review and Meta-Analysis of Clinical Studies.
Sun, Xuezheng; Abrahamson, Page; Ballew, Nicholas; Kalilani, Linda; Phiri, Kelesitse; Bell, Kelly F; Slowley, Alexander; Zajac, Magdalena; Hofstatter, Erin; Stojadinovic, Alexander; Silvestro, Angela; Wang, Zebin; Aziez, Amine; Peters, Solange.
Afiliación
  • Sun X; GSK, Research Triangle Park, NC, USA.
  • Abrahamson P; Salmon Bay Consulting, Seattle, WA, USA.
  • Ballew N; GSK, Collegeville, PA, USA.
  • Kalilani L; GSK, Research Triangle Park, NC, USA.
  • Phiri K; GSK, Collegeville, PA, USA.
  • Bell KF; GSK, Collegeville, PA, USA.
  • Slowley A; GSK, London, England, UK.
  • Zajac M; GSK, London, England, UK.
  • Hofstatter E; GSK, Waltham, MA, USA.
  • Stojadinovic A; GSK, Collegeville, PA, USA.
  • Silvestro A; GSK, Waltham, MA, USA.
  • Wang Z; GSK, Waltham, MA, USA.
  • Aziez A; GSK, Zug, Switzerland.
  • Peters S; Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.
Cancer Invest ; 41(6): 571-592, 2023 Jul.
Article en En | MEDLINE | ID: mdl-37272675
ABSTRACT
This systematic review with embedded meta-analysis aimed to evaluate the clinical utility of circulating tumor DNA (ctDNA) in lung cancer. After screening and review of the Embase database search, 111 studies from 2015 to 2020 demonstrated ctDNA's value in prognostication/monitoring disease progression, mainly in patients with advanced/metastatic disease and non-small cell lung cancer. ctDNA positivity/detection at any time point was associated with shorter progression-free survival and overall survival, whereas ctDNA clearance/decrease during treatment was associated with a lower risk of progression and death. Validating these findings and addressing challenges regarding ctDNA testing integration into clinical practice will require further research.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / ADN Tumoral Circulante / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Cancer Invest Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / ADN Tumoral Circulante / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Cancer Invest Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos