Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design.

Moussaoui, Dihia; Robblee, James P; Robert-Paganin, Julien; Auguin, Daniel; Fisher, Fabio; Fagnant, Patricia M; Macfarlane, Jill E; Schaletzky, Julia; Wehri, Eddie; Mueller-Dieckmann, Christoph; Baum, Jake; Trybus, Kathleen M; Houdusse, Anne

Moussaoui, Dihia; Robblee, James P; Robert-Paganin, Julien; Auguin, Daniel; Fisher, Fabio; Fagnant, Patricia M; Macfarlane, Jill E; Schaletzky, Julia; Wehri, Eddie; Mueller-Dieckmann, Christoph; Baum, Jake; Trybus, Kathleen M; Houdusse, Anne.

Afiliación

Moussaoui D; Structural Motility, Institut Curie, Université Paris Sciences et Lettres, Sorbonne Université, CNRS UMR144, 75248, Paris, France.
Robblee JP; Structural Biology group, European Synchrotron Radiation Facility (ESRF), 71, Avenue des Martyrs, 38000, Grenoble, France.
Robert-Paganin J; Department of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT, USA.
Auguin D; Structural Motility, Institut Curie, Université Paris Sciences et Lettres, Sorbonne Université, CNRS UMR144, 75248, Paris, France.
Fisher F; Structural Motility, Institut Curie, Université Paris Sciences et Lettres, Sorbonne Université, CNRS UMR144, 75248, Paris, France.
Fagnant PM; Laboratoire de Biologie des Ligneux et des Grandes Cultures (LBLGC), Université d'Orléans, INRAE, USC1328, Orléans, France.
Macfarlane JE; Department of Life Sciences, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK.
Schaletzky J; Department of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT, USA.
Wehri E; Department of Molecular Physiology & Biophysics, University of Vermont, Burlington, VT, USA.
Mueller-Dieckmann C; Center for Emerging and Neglected Diseases, Drug Discovery Center, Berkeley, CA, USA.
Baum J; Center for Emerging and Neglected Diseases, Drug Discovery Center, Berkeley, CA, USA.
Trybus KM; Structural Biology group, European Synchrotron Radiation Facility (ESRF), 71, Avenue des Martyrs, 38000, Grenoble, France.
Houdusse A; Department of Life Sciences, Imperial College London, Exhibition Road, South Kensington, London, SW7 2AZ, UK.

Nat Commun ; 14(1): 3463, 2023 06 12.

Article en En | MEDLINE | ID: mdl-37308472

Asunto(s)

Antimaláricos; Antagonistas del Ácido Fólico; Miosina Tipo IIA no Muscular; Plasmodium falciparum; Actinas; Bioensayo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Miosina Tipo IIA no Muscular / Antagonistas del Ácido Fólico / Antimaláricos Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2023 Tipo del documento: Article País de afiliación: Francia

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