Androgen receptor knockdown enhances prostate cancer chemosensitivity by down-regulating FEN1 through the ERK/ELK1 signalling pathway.

Xie, Weijie; Li, Shulin; Guo, Huan; Zhang, Jiawei; Tu, Menjiang; Wang, Rui; Lin, Bingling; Wu, Yuqi; Wang, Xiangwei

Xie, Weijie; Li, Shulin; Guo, Huan; Zhang, Jiawei; Tu, Menjiang; Wang, Rui; Lin, Bingling; Wu, Yuqi; Wang, Xiangwei.

Afiliación

Xie W; Department of Urology and Carson International Cancer Center, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Center, Shenzhen University, Shenzhen, People's Republic of China.
Li S; Department of Urology and Carson International Cancer Center, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Center, Shenzhen University, Shenzhen, People's Republic of China.
Guo H; Department of Urology, Affiliated Hospital of Guangdong Medical University, Guangdong Province, Zhanjiang, People's Republic of China.
Zhang J; Department of Urology and Carson International Cancer Center, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Center, Shenzhen University, Shenzhen, People's Republic of China.
Tu M; Department of Urology and Carson International Cancer Center, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Center, Shenzhen University, Shenzhen, People's Republic of China.
Wang R; Department of Urology and Carson International Cancer Center, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Center, Shenzhen University, Shenzhen, People's Republic of China.
Lin B; Department of Urology and Carson International Cancer Center, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Center, Shenzhen University, Shenzhen, People's Republic of China.
Wu Y; Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, People's Republic of China.
Wang X; Department of Urology and Carson International Cancer Center, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy Center, Shenzhen University, Shenzhen, People's Republic of China.

Cancer Med ; 12(14): 15317-15336, 2023 07.

Article en En | MEDLINE | ID: mdl-37326412

Asunto(s)

Neoplasias de la Próstata; Receptores Androgénicos; Masculino; Humanos; Receptores Androgénicos/genética; Receptores Androgénicos/metabolismo; Sistema de Señalización de MAP Quinasas; Endonucleasas de ADN Solapado/genética; Endonucleasas de ADN Solapado/metabolismo; Proliferación Celular; Línea Celular Tumoral; Neoplasias de la Próstata/tratamiento farmacológico; Neoplasias de la Próstata/genética; Neoplasias de la Próstata/metabolismo; Docetaxel/farmacología; ARN Interferente Pequeño/metabolismo; Proteína Elk-1 con Dominio ets/genética; Proteína Elk-1 con Dominio ets/metabolismo

Palabras clave

MAPK/ERK signalling pathway; androgen receptor; flap endonuclease 1; prostate cancer

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Receptores Androgénicos Límite: Humans / Male Idioma: En Revista: Cancer Med Año: 2023 Tipo del documento: Article

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