Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1.

Zheng, Mengmeng; Zhang, Yanmei; Xu, Yao; Han, Ying; Wu, Yingli; Kang, Jingwu

Zheng, Mengmeng; Zhang, Yanmei; Xu, Yao; Han, Ying; Wu, Yingli; Kang, Jingwu.

Afiliación

Zheng M; State Key Laboratory of Chemical Biology, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Zhang Y; University of Chinese Academy of Sciences, Beijing 101408, China.
Xu Y; State Key Laboratory of Chemical Biology, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Han Y; Institute for Agri-Food Standards and Testing Technology, Shanghai Academy of Agricultural Sciences, Shanghai 201403, China.
Wu Y; State Key Laboratory of Chemical Biology, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
Kang J; University of Chinese Academy of Sciences, Beijing 101408, China.

J Proteome Res ; 22(7): 2450-2459, 2023 07 07.

Article en En | MEDLINE | ID: mdl-37347238

Asunto(s)

Fosfatidilinositol 3-Quinasas; Transducción de Señal; Diana Mecanicista del Complejo 1 de la Rapamicina; Ligandos; Ácidos Cafeicos/farmacología

Palabras clave

chemoproteomics; covalent inhibitors; drug target identification; phosphoproteomics; salvianolic acid A

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Fosfatidilinositol 3-Quinasas Idioma: En Revista: J Proteome Res Asunto de la revista: BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: China

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