Electrochemical sensor based on the synergy between Cucurbit[8]uril and 2D-MoS2 for enhanced melatonin quantification.
Sci Rep
; 13(1): 10378, 2023 06 27.
Article
en En
| MEDLINE
| ID: mdl-37369678
ABSTRACT
We present the development of an electrochemical sensor towards melatonin determination based on the synergistic effect between MoS2 nanosheets and cucurbit[8]uril. For the sensor construction cucurbit[8]uril suspensions were prepared in water, and MoS2 nanosheets were obtained by liquid exfoliation in ethanolwater. The sensing platform was topographically characterized by Atomic Force Microscopy. Electrochemical Impedance Spectroscopy experiments allowed us to study the charge transfer process during melatonin oxidation. Moreover, stoichiometry of the resulting complex has also been determined. After the optimization of the sensor construction and the experimental variables involved in the Differential Pulse Voltammetric response of melatonin, detection limit of 3.80 × 10-7 M, relative errors minor than 3.8% and relative standard deviation lower than 4.4% were obtained. The proposed sensor has been successfully applied to melatonin determination in pharmaceutical and biological samples as human urine and serum, with very good recoveries ranging from 90 to 102%.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Melatonina
Límite:
Humans
Idioma:
En
Revista:
Sci Rep
Año:
2023
Tipo del documento:
Article
País de afiliación:
España