The gut-brain axis mediates bacterial driven modulation of reward signaling.
Mol Metab
; 75: 101764, 2023 09.
Article
en En
| MEDLINE
| ID: mdl-37380023
ABSTRACT
OBJECTIVE:
Our goal is to investigate if microbiota composition modulates reward signaling and assess the role of the vagus in mediating microbiota to brain communication.METHODS:
Male germ-free Fisher rats were colonized with gastrointestinal contents from chow (low fat (LF) ConvLF) or HF (ConvHF) fed rats.RESULTS:
Following colonization, ConvHF rats consumed significantly more food than ConvLF animals. ConvHF rats displayed lower feeding-induced extracellular DOPAC levels (a metabolite of dopamine) in the Nucleus Accumbens (NAc) as well as reduced motivation for HF foods compared to ConvLF rats. Dopamine receptor 2 (DDR2) expression levels in the NAc were also significantly lower in ConvHF animals. Similar deficits were observed in conventionally raised HF fed rats, showing that diet-driven alteration in reward can be initiated via microbiota. Selective gut to brain deafferentation restored DOPAC levels, DRD2 expression, and motivational drive in ConvHF rats.CONCLUSIONS:
We concluded from these data that a HF-type microbiota is sufficient to alter appetitive feeding behavior and that bacteria to reward communication is mediated by the vagus nerve.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Conducta Alimentaria
/
Eje Cerebro-Intestino
Límite:
Animals
Idioma:
En
Revista:
Mol Metab
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos