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Pathogenic Aß production by heterozygous PSEN1 mutations is intrinsic to the mutant protein and not mediated by conformational hindrance of wild-type PSEN1.
Kurth, Vanessa; Ogorek, Isabella; Münch, Carolina; Lopez-Rios, Javier; Ousson, Solenne; Lehmann, Sandra; Nieweg, Katja; Roebroek, Anton J M; Pietrzik, Claus U; Beher, Dirk; Weggen, Sascha.
Afiliación
  • Kurth V; Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
  • Ogorek I; Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany; Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
  • Münch C; Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
  • Lopez-Rios J; Centro Andaluz de Biología del Desarrollo (CABD), CSIC-Universidad Pablo de Olavide-Junta de Andalucia, Sevilla, Spain.
  • Ousson S; Asceneuron SA, Lausanne, Switzerland.
  • Lehmann S; Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany.
  • Nieweg K; Institute of Pharmacology and Clinical Pharmacy, Philipps-University, Marburg, Germany.
  • Roebroek AJM; Department of Human Genetics, KU Leuven, Leuven, Belgium.
  • Pietrzik CU; Institute of Pathobiochemistry, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
  • Beher D; Asceneuron SA, Lausanne, Switzerland.
  • Weggen S; Department of Neuropathology, Heinrich Heine University, Düsseldorf, Germany. Electronic address: sweggen@hhu.de.
J Biol Chem ; 299(8): 104997, 2023 08.
Article en En | MEDLINE | ID: mdl-37394008
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Secretasas de la Proteína Precursora del Amiloide / Enfermedad de Alzheimer Límite: Animals Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: Alemania