Novel aminopyridazine derivative of minaprine modified by radiolysis presents potent anti-inflammatory effects in LPS-stimulated RAW 264.7 and DH82 macrophage cells.

Jeong, Gyeong Han; Lee, Hanui; Woo, So-Yeun; Lee, Hong-Ki; Chung, Byung Yeoup; Bai, Hyoung-Woo

Jeong, Gyeong Han; Lee, Hanui; Woo, So-Yeun; Lee, Hong-Ki; Chung, Byung Yeoup; Bai, Hyoung-Woo.

Afiliación

Jeong GH; Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup, 56212, Republic of Korea.
Lee H; Center for Companion Animal New Drug Development, Korea Institute of Toxicology (KIT), Jeongeup, 56212, Republic of Korea.
Woo SY; Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup, 56212, Republic of Korea.
Lee HK; Center for Companion Animal New Drug Development, Korea Institute of Toxicology (KIT), Jeongeup, 56212, Republic of Korea.
Chung BY; Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), Jeongeup, 56212, Republic of Korea.
Bai HW; Center for Companion Animal New Drug Development, Korea Institute of Toxicology (KIT), Jeongeup, 56212, Republic of Korea.

Sci Rep ; 13(1): 10887, 2023 07 05.

Article en En | MEDLINE | ID: mdl-37407652

Asunto(s)

Lipopolisacáridos; FN-kappa B; Animales; Ratones; Lipopolisacáridos/farmacología; Lipopolisacáridos/metabolismo; FN-kappa B/metabolismo; Macrófagos/metabolismo; Óxido Nítrico Sintasa de Tipo II/metabolismo; Antiinflamatorios/química; Ciclooxigenasa 2/metabolismo; Óxido Nítrico/metabolismo; Células RAW 264.7

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Lipopolisacáridos / FN-kappa B Límite: Animals Idioma: En Revista: Sci Rep Año: 2023 Tipo del documento: Article

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