Aberrant KAT2A accumulations render TRIM22-low melanoma sensitive to Notch1 inhibitors via epigenetic reprogramming.

Gu, Xiaoli; Min, Wei; Zeng, Yibin; Fan, Ni; Qian, Qihong

Gu, Xiaoli; Min, Wei; Zeng, Yibin; Fan, Ni; Qian, Qihong.

Afiliación

Gu X; Department of Dermatology, The First Affiliated Hospital of Soochow University, Pinghai Road 899, Suzhou, 215006, China.
Min W; Department of Dermatology, The First Affiliated Hospital of Soochow University, Pinghai Road 899, Suzhou, 215006, China.
Zeng Y; Department of Dermatology, The First Affiliated Hospital of Soochow University, Pinghai Road 899, Suzhou, 215006, China.
Fan N; Department of Dermatology, The First Affiliated Hospital of Soochow University, Pinghai Road 899, Suzhou, 215006, China.
Qian Q; Department of Dermatology, The First Affiliated Hospital of Soochow University, Pinghai Road 899, Suzhou, 215006, China. qianqihongsuda@163.com.

J Transl Med ; 21(1): 443, 2023 07 06.

Article en En | MEDLINE | ID: mdl-37415153

Asunto(s)

Melanoma; Humanos; Línea Celular Tumoral; Melanoma/genética; Transducción de Señal; Ubiquitinación; Epigénesis Genética; Proteínas de Motivos Tripartitos/genética; Proteínas de Motivos Tripartitos/metabolismo; Proteínas Represoras/genética; Antígenos de Histocompatibilidad Menor/metabolismo; Histona Acetiltransferasas/genética; Histona Acetiltransferasas/metabolismo

Palabras clave

KAT2A; Melanoma; Nocth1 signaling; TRIM22; Ubiquitination

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Melanoma Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: J Transl Med Año: 2023 Tipo del documento: Article País de afiliación: China

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