A new approach with dried plasma spots: a rapid determination of antidepressants and antipsychotics by fast GC-MS.
Bioanalysis
; 15(16): 1021-1032, 2023 Aug.
Article
en En
| MEDLINE
| ID: mdl-37431824
ABSTRACT
Background:
The increasing prevalence of poisoning cases related to antidepressants and antipsychotics has raised concerns.Methods:
To address this issue, a new adaptation of the dried plasma spot technique was developed using a 24-well plate and fast gas chromatography-mass spectrometry. The method involves the optimization of extraction variables and sample preparation, and was successfully validated.Results:
The limits of quantitation ranged from 20 to 60 ng/ml, and accuracy ranged from 87.8% to 112.2%. The technique was applied to 102 human plasma samples from suspected poisoning cases, with positivity of 90.2%.Conclusion:
This method provides a cheap, easy to implement and fast approach, making it ideal for toxicological emergency laboratories and promoting valuable support for healthcare professionals managing poisoning cases involving antidepressants and antipsychotics.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Antipsicóticos
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Bioanalysis
Año:
2023
Tipo del documento:
Article
País de afiliación:
Brasil