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Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.
Murray, Aoife; Gough, Gillian; Cindric, Ana; Vuckovic, Frano; Koschut, David; Borelli, Vincenzo; Petrovic, Drazen J; Bekavac, Ana; Plecas, Ante; Hribljan, Valentina; Brunmeir, Reinhard; Juric, Julija; Pucic-Bakovic, Maja; Slana, Anita; Deris, Helena; Frkatovic, Azra; Groet, Jurgen; O'Brien, Niamh L; Chen, Hong Yu; Yeap, Yee Jie; Delom, Frederic; Havlicek, Steven; Gammon, Luke; Hamburg, Sarah; Startin, Carla; D'Souza, Hana; Mitrecic, Dinko; Kero, Mijana; Odak, Ljubica; Kruslin, Bozo; Krsnik, Zeljka; Kostovic, Ivica; Foo, Jia Nee; Loh, Yuin-Han; Dunn, Norris Ray; de la Luna, Susana; Spector, Tim; Barisic, Ingeborg; Thomas, Michael S C; Strydom, Andre; Franceschi, Claudio; Lauc, Gordan; Kristic, Jasminka; Alic, Ivan; Nizetic, Dean.
Afiliación
  • Murray A; Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK; The London Down Syndrome Consortium (LonDownS), London, UK. Electronic address: aoife.murray@qmul.ac.uk.
  • Gough G; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
  • Cindric A; Glycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia.
  • Vuckovic F; Glycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia.
  • Koschut D; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Disease Intervention Technology Laboratory (DITL), Institute of Molecular and Cellular Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), Singapore.
  • Borelli V; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Italy.
  • Petrovic DJ; Glycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia; Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Bekavac A; Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Plecas A; Faculty of Veterinary Medicine, Department of Anatomy, Histology and Embryology, University of Zagreb, Zagreb, Croatia.
  • Hribljan V; Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Brunmeir R; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
  • Juric J; Glycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia.
  • Pucic-Bakovic M; Glycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia.
  • Slana A; Glycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia.
  • Deris H; Glycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia.
  • Frkatovic A; Glycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia.
  • Groet J; Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK; The London Down Syndrome Consortium (LonDownS), London, UK.
  • O'Brien NL; Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK; The London Down Syndrome Consortium (LonDownS), London, UK.
  • Chen HY; Institute of Molecular and Cell Biology (IMCB), A∗STAR, Singapore.
  • Yeap YJ; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
  • Delom F; Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK.
  • Havlicek S; Laboratory of Neurogenetics, Genome Institute of Singapore, A∗STAR, Singapore.
  • Gammon L; Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK.
  • Hamburg S; The London Down Syndrome Consortium (LonDownS), London, UK.
  • Startin C; The London Down Syndrome Consortium (LonDownS), London, UK; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Division of Psychiatry, University College London, London, UK; School of Psychology, University
  • D'Souza H; The London Down Syndrome Consortium (LonDownS), London, UK; Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK.
  • Mitrecic D; Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Kero M; Department of Medical Genetics, Children's Hospital Zagreb, Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Odak L; Department of Medical Genetics, Children's Hospital Zagreb, Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Kruslin B; Department of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Krsnik Z; Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Kostovic I; Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Foo JN; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Laboratory of Neurogenetics, Genome Institute of Singapore, A∗STAR, Singapore.
  • Loh YH; Institute of Molecular and Cell Biology (IMCB), A∗STAR, Singapore.
  • Dunn NR; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Institute of Molecular and Cell Biology (IMCB), A∗STAR, Singapore.
  • de la Luna S; ICREA, Genome Biology Programme (CRG), Universitat Pompeu Fabra (UPF), CIBER of Rare Diseases, Barcelona, Spain.
  • Spector T; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Barisic I; Department of Medical Genetics, Children's Hospital Zagreb, Centre of Excellence for Reproductive and Regenerative Medicine, School of Medicine, University of Zagreb, Zagreb, Croatia.
  • Thomas MSC; The London Down Syndrome Consortium (LonDownS), London, UK; Centre for Brain and Cognitive Development, Birkbeck, University of London, London, UK.
  • Strydom A; The London Down Syndrome Consortium (LonDownS), London, UK; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Division of Psychiatry, University College London, London, UK.
  • Franceschi C; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Italy; Institute of Information Technologies, Mathematics and Mechanics, Lobachevsky State University, Nizhny Novgorod 603022, Russia.
  • Lauc G; Glycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia.
  • Kristic J; Glycoscience Research Laboratory, Genos Ltd., Zagreb, Croatia. Electronic address: jkristic@genos.hr.
  • Alic I; Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK; Faculty of Veterinary Medicine, Department of Anatomy, Histology and Embryology, University of Zagreb, Zagreb, Croatia. Electronic address: i.alic@qmul.ac.uk.
  • Nizetic D; Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK; The London Down Syndrome Consortium (LonDownS), London, UK; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. Electronic address: d.nizetic@qmul.ac.uk.
EBioMedicine ; 94: 104692, 2023 Aug.
Article en En | MEDLINE | ID: mdl-37451904
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndrome de Down / Células Madre Pluripotentes Inducidas Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Humans Idioma: En Revista: EBioMedicine Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Síndrome de Down / Células Madre Pluripotentes Inducidas Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Humans Idioma: En Revista: EBioMedicine Año: 2023 Tipo del documento: Article