Clinical evidence for a role of E2F1-induced replication stress in modulating tumor mutational burden and immune microenvironment.

Tan, Ke; Song, Yizhe; Xu, Min; You, Zhongsheng

Tan, Ke; Song, Yizhe; Xu, Min; You, Zhongsheng.

Afiliación

Tan K; Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212013, China; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Song Y; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63110, USA.
Xu M; Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212013, China.
You Z; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: zyou@wustl.edu.

DNA Repair (Amst) ; 129: 103531, 2023 09.

Article en En | MEDLINE | ID: mdl-37453246

Asunto(s)

Replicación del ADN; Neoplasias; Humanos; Neoplasias/genética; Mutación; Biomarcadores de Tumor; ADN; Carcinogénesis; Microambiente Tumoral; Factor de Transcripción E2F1/genética

Palabras clave

Cytosolic self-DNA; E2F1; Replication stress; Tumor immune microenvironment; Tumor mutational burden

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Replicación del ADN / Neoplasias Límite: Humans Idioma: En Revista: DNA Repair (Amst) Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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