Alectinib-induced rash unresponsive to desensitization: a case report and literature review.
BMC Pulm Med
; 23(1): 261, 2023 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-37454087
ABSTRACT
BACKGROUND:
Since the inception of targeted therapies in treating lung cancer, providers have had to be aware of a new host of side effects when selecting management options for patients. Although targeted therapies are creating increased hope for patients with non-small cell lung cancers (NSCLC), understanding their side effects presents a challenge for providers. Alectinib, a second-generation tyrosine kinase inhibitor, is a targeted therapy used in patients with non-small cell lung cancer found to have anaplastic lymphoma kinase (ALK) mutations. Alectinib is the focus of this case report and literature review as we seek to understand side effects providers may encounter when prescribing these therapies. CASE PRESENTATION We begin our report with the case of a 63-year-old Hispanic female with stage IIIA non-small cell lung cancer found to have the ALK genomic alteration. She was started on Alectinib, and on Day 11, she developed a severe maculopapular rash requiring hospitalization. After complete resolution, desensitization with Alectinib was attempted but unsuccessful.CONCLUSIONS:
Despite the unsuccessful desensitization of this patient, it is important to report this rare side effect in order to better understand how providers can pursue management. Case reports such as this can aid providers in potentially preventing, treating, and rechallenging patients on targeted therapies in the future.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Pulmón de Células no Pequeñas
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Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos
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Exantema
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Neoplasias Pulmonares
Límite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
BMC Pulm Med
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos