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Oxysterol-Binding Protein: new insights into lipid transport functions and human diseases.
Lin, Yani; Ran, Liyuan; Du, Ximing; Yang, Hongyuan; Wu, Yingjie.
Afiliación
  • Lin Y; Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250021, China.
  • Ran L; Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250021, China; Institute for Genome Engineered Animal Models of H
  • Du X; School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW 2052, Australia.
  • Yang H; School of Biotechnology and Biomolecular Sciences, the University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: H.Rob.Yang@unsw.edu.au.
  • Wu Y; Shandong Provincial Hospital, School of Laboratory Animal & Shandong Laboratory Animal Center, Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong 250021, China; Institute for Genome Engineered Animal Models of H
Biochim Biophys Acta Mol Cell Biol Lipids ; 1868(9): 159365, 2023 09.
Article en En | MEDLINE | ID: mdl-37455011
Oxysterol-binding protein (OSBP) mediates lipid exchange between organelles at membrane contact sites, thereby regulating lipid dynamics and homeostasis. How OSBP's lipid transfer function impacts health and disease remain to be elucidated. In this review, we first summarize the structural characteristics and lipid transport functions of OSBP, and then focus on recent progresses linking OSBP with fatty liver disease, diabetes, lysosome-related diseases, cancer and viral infections, with the aim of discovering novel therapeutic strategies for common human diseases.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transporte Biológico / Metabolismo de los Lípidos / Oxiesteroles Límite: Humans Idioma: En Revista: Biochim Biophys Acta Mol Cell Biol Lipids Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transporte Biológico / Metabolismo de los Lípidos / Oxiesteroles Límite: Humans Idioma: En Revista: Biochim Biophys Acta Mol Cell Biol Lipids Año: 2023 Tipo del documento: Article País de afiliación: China