Vascular endothelial growth factor gene insertion/deletion polymorphism is associated with Vitamin D level in Turkish patients with coronavirus disease 2019.
Rev Assoc Med Bras (1992)
; 69(7): e20221713, 2023.
Article
en En
| MEDLINE
| ID: mdl-37466590
ABSTRACT
OBJECTIVE:
Coronavirus disease 2019 emerges as a disease caused by severe acute respiratory syndrome coronavirus 2. It is a systemic disease associated with vascular inflammation and endothelial damage. In this study, we aimed to investigate whether vascular endothelial growth factor gene insertion/deletion polymorphism is associated with coronavirus disease 2019 in the Turkish population.METHODS:
The study included 179 participants (79 patients with coronavirus disease 2019 and 100 controls). DNA isolation was made from peripheral blood, and then the polymerase chain reaction analysis was performed.RESULTS:
When we analyze vascular endothelial growth factor gene insertion/deletion polymorphism in the study group, we found that the DD genotype and D allele were found to be statistically significantly different when compared to coronavirus disease 2019 patients with high vitamin D value (p=0.005 for DD genotype and p=0.006 for D allele) in the control group. In this high-level control group, when we analyze II+ID genotype versus DD, a statistically significant difference was also detected (p=0.007).CONCLUSION:
As a result of the study, we found that DD genotype and D allele were associated with vitamin D level in Turkish patients with coronavirus disease 2019.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Factor A de Crecimiento Endotelial Vascular
/
COVID-19
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Rev Assoc Med Bras (1992)
Año:
2023
Tipo del documento:
Article
País de afiliación:
Turquía