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Discovery of novel resorcinol biphenyl ether-based macrocyclic small molecules as PD-1/PD-L1 inhibitors with favorable pharmacokinetics for cancer immunotherapy.
Yang, Zichao; Liu, Ziqing; Xu, Chenglong; Xu, Jianwei; Liu, Ting; He, Haiqi; Li, Ling; Ren, Yichang; Chen, Jianjun.
Afiliación
  • Yang Z; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Liu Z; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Xu C; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Xu J; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Liu T; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • He H; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Li L; The Eighth Affiliated Hospital, Sun Yat sen University, Shenzhen 518033, China.
  • Ren Y; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Chen J; Guangdong Provincial Key Laboratory of New Drug Screening, NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: jchen21@smu.edu.cn.
Bioorg Chem ; 139: 106740, 2023 10.
Article en En | MEDLINE | ID: mdl-37478546
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antígeno B7-H1 / Neoplasias Límite: Animals Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Antígeno B7-H1 / Neoplasias Límite: Animals Idioma: En Revista: Bioorg Chem Año: 2023 Tipo del documento: Article País de afiliación: China