Understanding virus-host interactions in tissues.
Nat Microbiol
; 8(8): 1397-1407, 2023 08.
Article
en En
| MEDLINE
| ID: mdl-37488255
ABSTRACT
Although virus-host interactions are usually studied in a single cell type using in vitro assays in immortalized cell lines or isolated cell populations, it is important to remember that what is happening inside one infected cell does not translate to understanding how an infected cell behaves in a tissue, organ or whole organism. Infections occur in complex tissue environments, which contain a host of factors that can alter the course of the infection, including immune cells, non-immune cells and extracellular-matrix components. These factors affect how the host responds to the virus and form the basis of the protective response. To understand virus infection, tools are needed that can profile the tissue environment. This Review highlights methods to study virus-host interactions in the infection microenvironment.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Virus
/
Virosis
Límite:
Humans
Idioma:
En
Revista:
Nat Microbiol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos