Therapeutic Applications of Azanucleoside Analogs as DNA Demethylating Agents.
Epigenomes
; 7(3)2023 Jul 05.
Article
en En
| MEDLINE
| ID: mdl-37489400
ABSTRACT
Azanucleosides, such as 5-azacytidine and decitabine, are DNA demethylating agents used in the treatment of acute myeloid leukemia and myelodysplastic syndromes. Researchers continue to explore their utility in the treatment of other hematologic and solid tumors. Based on the capacity of the compounds to inhibit DNA methyltransferase enzymes and the important role of DNA methylation in health and disease, it is essential to understand the molecular changes that azanucleosides induce and how these changes may improve treatment outcomes in subsets of patients. This review summarizes the molecular and therapeutic actions of azanucleosides and discusses recent clinical trials of these compounds as single agents or in combination therapy for the treatment of cancer and related conditions.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Epigenomes
Año:
2023
Tipo del documento:
Article
País de afiliación:
Estados Unidos