Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep-wake Disturbances in AD Mice.

Yao, Annie Y; Halloran, Patrick J; Ge, Yingying; Singh, Neeraj; Zhou, John; Galske, James; He, Wanxia; Yan, Riqiang; Hu, Xiangyou

Yao, Annie Y; Halloran, Patrick J; Ge, Yingying; Singh, Neeraj; Zhou, John; Galske, James; He, Wanxia; Yan, Riqiang; Hu, Xiangyou.

Afiliación

Yao AY; Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030.
Halloran PJ; Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030.
Ge Y; Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030.
Singh N; Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030.
Zhou J; Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030.
Galske J; Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030.
He W; Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030.
Yan R; Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 riyan@uchc.edu xhu@uchc.edu.
Hu X; Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 riyan@uchc.edu xhu@uchc.edu.

J Neurosci ; 43(35): 6197-6211, 2023 08 30.

Article en En | MEDLINE | ID: mdl-37536983

Asunto(s)

Enfermedad de Alzheimer; Trastornos del Sueño-Vigilia; Ratones; Animales; Enfermedad de Alzheimer/complicaciones; Enfermedad de Alzheimer/tratamiento farmacológico; Enfermedad de Alzheimer/genética; Ratones Transgénicos; Secretasas de la Proteína Precursora del Amiloide/metabolismo; Ácido Aspártico Endopeptidasas/genética; Ácido Aspártico Endopeptidasas/metabolismo; Placa Amiloide; Convulsiones; Trastornos del Sueño-Vigilia/etiología; Trastornos del Sueño-Vigilia/genética; Sueño; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Péptidos beta-Amiloides/metabolismo; Modelos Animales de Enfermedad

Palabras clave

Alzheimer's disease; BACE1; NREM; REM; epileptic; sleep disturbance

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Trastornos del Sueño-Vigilia / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Guideline Límite: Animals Idioma: En Revista: J Neurosci Año: 2023 Tipo del documento: Article

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