A Novel "Activation Switch" Motif Common to All Aminergic Receptors.

Lee, Kuo Hao; Manning, Jamie J; Javitch, Jonathan; Shi, Lei

Lee, Kuo Hao; Manning, Jamie J; Javitch, Jonathan; Shi, Lei.

Afiliación

Lee KH; Computational Chemistry and Molecular Biophysics Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug AbuseâIntramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, United States.
Manning JJ; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York 10032, United States.
Javitch J; Department of Molecular Pharmacology and Therapeutics, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032, United States.
Shi L; Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York 10032, United States.

J Chem Inf Model ; 63(16): 5001-5017, 2023 08 28.

Article en En | MEDLINE | ID: mdl-37540602

Asunto(s)

Receptores Acoplados a Proteínas G; Transducción de Señal; Conformación Proteica; Ligandos; Receptores Acoplados a Proteínas G/química; Proteínas de Unión al GTP/metabolismo; Sitios de Unión

Palabras clave

aminergic receptors; conformational analysis; cryo-EM structures; crystal structures; ligand binding pocket; receptor activation

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Receptores Acoplados a Proteínas G Idioma: En Revista: J Chem Inf Model Asunto de la revista: INFORMATICA MEDICA / QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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