Off-target pharmacological activity at various kinases: Potential functional and pathological side effects.

Green, Jonathon R; Mahalingaiah, Prathap Kumar S; Gopalakrishnan, Sujatha M; Liguori, Michael J; Mittelstadt, Scott W; Blomme, Eric A G; Van Vleet, Terry R

Green, Jonathon R; Mahalingaiah, Prathap Kumar S; Gopalakrishnan, Sujatha M; Liguori, Michael J; Mittelstadt, Scott W; Blomme, Eric A G; Van Vleet, Terry R.

Afiliación

Green JR; Departments of Preclinical Safety, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, United States. Electronic address: jonathon.green@abbvie.com.
Mahalingaiah PKS; Departments of Preclinical Safety, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, United States.
Gopalakrishnan SM; Drug Discovery Science and Technology, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, United States.
Liguori MJ; Departments of Preclinical Safety, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, United States.
Mittelstadt SW; Departments of Preclinical Safety, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, United States.
Blomme EAG; Departments of Preclinical Safety, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, United States.
Van Vleet TR; Departments of Preclinical Safety, AbbVie, 1 North Waukegan Road, North Chicago, IL 60064, United States.

J Pharmacol Toxicol Methods ; 123: 107468, 2023.

Article en En | MEDLINE | ID: mdl-37553032

Asunto(s)

Descubrimiento de Drogas; Bases de Datos Factuales

Palabras clave

Activation; Drug Discovery; Functional; Inhibition; Interaction; Kinase; Off-target; Pathological; Safety; Side effect; Table

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Descubrimiento de Drogas Tipo de estudio: Prognostic_studies Idioma: En Revista: J Pharmacol Toxicol Methods Asunto de la revista: FARMACOLOGIA / TOXICOLOGIA Año: 2023 Tipo del documento: Article

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