Gastrointestinal Dysfunction in Stroke.
Semin Neurol
; 43(4): 609-625, 2023 08.
Article
en En
| MEDLINE
| ID: mdl-37562458
ABSTRACT
Gastrointestinal (GI) complications are seen in over 50% of ischemic stroke survivors; the most common complications are dysphagia, constipation, and GI bleeding. The bidirectional relationship of the gut-brain axis and stroke has recently gained traction, wherein stroke contributes to gut dysbiosis (alterations in the normal host intestinal microbiome) and gut dysbiosis perpetuates poor functional neurologic outcomes in stroke. It is postulated that the propagation of proinflammatory cells and gut metabolites (including trimethylamine N-oxide and short-chain fatty acids) from the GI tract to the central nervous system play a central role in gut-brain axis dysfunction. In this review, we discuss the known GI complications in acute ischemic stroke, our current knowledge from experimental stroke models for gut-brain axis dysfunction in stroke, and emerging therapeutics that target the gut-brain axis.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Accidente Cerebrovascular
/
Enfermedades Gastrointestinales
/
Accidente Cerebrovascular Isquémico
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Semin Neurol
Año:
2023
Tipo del documento:
Article
País de afiliación:
Canadá