A one-pot synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic acid and DMF derivatives using imidazole hydrochloride as a promoter.
Curr Org Synth
; 2023 Aug 15.
Article
en En
| MEDLINE
| ID: mdl-37581515
ABSTRACT
As a novel and environmentally friendly Brönsted acid, imidazole hydrochloride was used to promote the synthesis of 2,3-disubstituted-4(3H)-quinazolinone from o-aminobenzoic acid and DMF derivatives. The essence of this reaction is a multicomponent reaction, which constructs multiple chemical bonds between different components through the transamidation of imidazole hydrochloride. This protocol showed a wide range of functional group tolerance, and a series of quinazolinones were synthesized in low to moderate yields without metal catalysts, oxidants or other additives.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Curr Org Synth
Año:
2023
Tipo del documento:
Article