IFNÉ£ but not IFN&#945; increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity.

Thomaidou, Sofia; Munoz Garcia, Amadeo; de Lange, Sabine; Gan, Jin; van der Slik, Arno R; Hoeben, Rob C; Roep, Bart O; Carlotti, Françoise; Zaldumbide, Arnaud

IFNÉ£ but not IFNα increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity.

Thomaidou, Sofia; Munoz Garcia, Amadeo; de Lange, Sabine; Gan, Jin; van der Slik, Arno R; Hoeben, Rob C; Roep, Bart O; Carlotti, Françoise; Zaldumbide, Arnaud.

Afiliación

Thomaidou S; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. thomaidousofia@gmail.com.
Munoz Garcia A; Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
de Lange S; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Gan J; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
van der Slik AR; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Hoeben RC; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Roep BO; Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Carlotti F; Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
Zaldumbide A; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands. a.zaldumbide@lumc.nl.

Diabetologia ; 66(11): 2075-2086, 2023 11.

Article en En | MEDLINE | ID: mdl-37581620

Asunto(s)

Diabetes Mellitus Tipo 1; Células Secretoras de Insulina; Islotes Pancreáticos; Humanos; Insulina/metabolismo; Diabetes Mellitus Tipo 1/metabolismo; Autoinmunidad; Islotes Pancreáticos/metabolismo; Interferón-alfa/farmacología; Células Secretoras de Insulina/metabolismo; Interferón gamma/farmacología; Interferón gamma/metabolismo

Palabras clave

Autoantigens; Degradation; Inflammation; Proteasome; Type 1 diabetes

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Islotes Pancreáticos / Diabetes Mellitus Tipo 1 / Células Secretoras de Insulina Límite: Humans Idioma: En Revista: Diabetologia Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos

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