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Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization.
Taquet, Maxime; Skorniewska, Zuzanna; Hampshire, Adam; Chalmers, James D; Ho, Ling-Pei; Horsley, Alex; Marks, Michael; Poinasamy, Krisnah; Raman, Betty; Leavy, Olivia C; Richardson, Matthew; Elneima, Omer; McAuley, Hamish J C; Shikotra, Aarti; Singapuri, Amisha; Sereno, Marco; Saunders, Ruth M; Harris, Victoria C; Houchen-Wolloff, Linzy; Greening, Neil J; Mansoori, Parisa; Harrison, Ewen M; Docherty, Annemarie B; Lone, Nazir I; Quint, Jennifer; Sattar, Naveed; Brightling, Christopher E; Wain, Louise V; Evans, Rachael E; Geddes, John R; Harrison, Paul J.
Afiliación
  • Taquet M; Department of Psychiatry, University of Oxford, Oxford, UK. maxime.taquet@psych.ox.ac.uk.
  • Skorniewska Z; Oxford Health NHS Foundation Trust, Oxford, UK. maxime.taquet@psych.ox.ac.uk.
  • Hampshire A; Department of Psychiatry, University of Oxford, Oxford, UK.
  • Chalmers JD; Department of Brain Sciences, Imperial College London, London, UK.
  • Ho LP; University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
  • Horsley A; MRC Human Immunology Unit, University of Oxford, Oxford, UK.
  • Marks M; Division of Infection, Immunity & Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
  • Poinasamy K; Manchester University NHS Foundation Trust, Manchester, UK.
  • Raman B; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
  • Leavy OC; Hospital for Tropical Diseases, University College London Hospital, London, UK.
  • Richardson M; Division of Infection and Immunity, University College London, London, UK.
  • Elneima O; Asthma and Lung UK, London, UK.
  • McAuley HJC; Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
  • Shikotra A; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Singapuri A; Department of Population Health Sciences, University of Leicester, Leicester, UK.
  • Sereno M; The institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Saunders RM; The institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Harris VC; The institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Houchen-Wolloff L; The institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Greening NJ; NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Mansoori P; The institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Harrison EM; The institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Docherty AB; The institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Lone NI; The institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Quint J; University Hospitals of Leicester NHS Trust, Leicester, UK.
  • Sattar N; Centre for Exercise and Rehabilitation Science, NIHR Leicester Biomedical Research Centre-Respiratory, University of Leicester, Leicester, UK.
  • Brightling CE; Department of Respiratory Sciences, University of Leicester, Leicester, UK.
  • Wain LV; Therapy Department, University Hospitals of Leicester, NHS Trust, Leicester, UK.
  • Evans RE; The institute for Lung Health, NIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
  • Geddes JR; MQ: Transforming Mental Health, London, UK.
  • Harrison PJ; Centre for Medical Informatics, The Usher Institute, University of Edinburgh, Edinburgh, UK.
Nat Med ; 29(10): 2498-2508, 2023 10.
Article en En | MEDLINE | ID: mdl-37653345
ABSTRACT
Post-COVID cognitive deficits, including 'brain fog', are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the ability to work, yet their biological underpinnings remain unknown. In this prospective cohort study of 1,837 adults hospitalized with COVID-19, we identified two distinct biomarker profiles measured during the acute admission, which predict cognitive outcomes 6 and 12 months after COVID-19. A first profile links elevated fibrinogen relative to C-reactive protein with both objective and subjective cognitive deficits. A second profile links elevated D-dimer relative to C-reactive protein with subjective cognitive deficits and occupational impact. This second profile was mediated by fatigue and shortness of breath. Neither profile was significantly mediated by depression or anxiety. Results were robust across secondary analyses. They were replicated, and their specificity to COVID-19 tested, in a large-scale electronic health records dataset. These findings provide insights into the heterogeneous biology of post-COVID cognitive deficits.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína C-Reactiva / COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
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Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteína C-Reactiva / COVID-19 Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans Idioma: En Revista: Nat Med Asunto de la revista: BIOLOGIA MOLECULAR / MEDICINA Año: 2023 Tipo del documento: Article País de afiliación: Reino Unido