The Effectiveness and Safety of First-Line Thioguanine in Thiopurine-Naïve Inflammatory Bowel Disease Patients.

Crouwel, Femke; Bayoumy, Ahmed B; Mulder, Chris J J; Peters, Job H C; Boekema, Paul J; Derijks, Luc J J; de Boer, Sybrand Y; van de Meeberg, Paul C; Ahmad, Ishfaq; Buiter, Hans J C; de Boer, Nanne K

Crouwel, Femke; Bayoumy, Ahmed B; Mulder, Chris J J; Peters, Job H C; Boekema, Paul J; Derijks, Luc J J; de Boer, Sybrand Y; van de Meeberg, Paul C; Ahmad, Ishfaq; Buiter, Hans J C; de Boer, Nanne K.

Afiliación

Crouwel F; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Bayoumy AB; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Mulder CJJ; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Peters JHC; Department of Gastroenterology and Hepatology, Rode Kruis hospital, Beverwijk, the Netherlands.
Boekema PJ; Department of Gastroenterology and Hepatology, Máxima Medical Centre, Veldhoven, the Netherlands.
Derijks LJJ; Department of Clinical Pharmacy and Pharmacology, Máxima Medical Centre, Veldhoven, the Netherlands.
de Boer SY; Department of Gastroenterology and Hepatology, Slingeland Hospital, Doetinchem, the Netherlands.
van de Meeberg PC; Department of Gastroenterology and Hepatology, Slingeland Hospital, Doetinchem, the Netherlands.
Ahmad I; Department of Gastroenterology and Hepatology, Streekziekenhuis Koningin Beatrix, Winterswijk, the Netherlands.
Buiter HJC; Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
de Boer NK; Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Inflamm Bowel Dis ; 2023 Sep 02.

Article en En | MEDLINE | ID: mdl-37658804

After 12 months, first-line thioguanine therapy was still used by 86% of thiopurine-naïve patients with inflammatory bowel disease and clinically effective in 53%. The safety profile was acceptable and only 8% of patients ceased therapy due to adverse events.

Palabras clave

clinical effectiveness; inflammatory bowel disease; thioguanine

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Observational_studies Idioma: En Revista: Inflamm Bowel Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2023 Tipo del documento: Article País de afiliación: Países Bajos

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