Reduction of quantal size by vesamicol (AH5183), an inhibitor of vesicular acetylcholine storage.
Brain Res
; 385(1): 189-92, 1986 Oct 15.
Article
en En
| MEDLINE
| ID: mdl-3768717
ABSTRACT
Isolated unparalysed mouse phrenic nerve-hemidiaphragm preparations were indirectly stimulated in the presence of 2-(4-phenylpiperidino)cyclohexanol (AH5183, vesamicol). Spontaneous miniature endplate potentials were subsequently studied. They exhibited a large depression of amplitude which was more profound at higher stimulation frequencies and drug concentration. No post-junctional effects of the drug were observed. Since the drug blocks storage of acetylcholine by isolated synaptic vesicles, it is argued that the results support the theory of vesicular release of acetylcholine.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fenciclidina
/
Piperidinas
/
Vesículas Sinápticas
/
Acetilcolina
/
Fármacos Neuromusculares Despolarizantes
/
Unión Neuromuscular
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1986
Tipo del documento:
Article