Detection of mesenchymal chondrosarcoma in pleural effusion with immunocytochemistry and determination of HEY1::NCOA2 fusion by next-generation sequencing on cell block.

Zhong, Jingmin; Wang, Qingjie; Xie, Yilin; Niu, Zhaorong; Zhou, Diwei

Zhong, Jingmin; Wang, Qingjie; Xie, Yilin; Niu, Zhaorong; Zhou, Diwei.

Afiliación

Zhong J; Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang Q; Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xie Y; Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Niu Z; Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhou D; Pathology Department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Cytopathology ; 35(1): 149-152, 2024 Jan.

Article en En | MEDLINE | ID: mdl-37688410

ABSTRACT

ABSTRACT

Mesenchymal chondrosarcoma (MC) is a rare but extremely aggressive type of chondrosarcoma distinguished by the presence of both primitive mesenchymal cells and fully developed chondroid tissue. The identification of a biphasic morphology in pleural effusion, along with detection of the HEY1NCOA2 fusion using next-generation sequencing, serve as vital indicators for an accurate diagnosis.

Asunto(s)

Neoplasias Óseas; Condrosarcoma Mesenquimal; Derrame Pleural; Humanos; Condrosarcoma Mesenquimal/diagnóstico; Condrosarcoma Mesenquimal/genética; Condrosarcoma Mesenquimal/metabolismo; Inmunohistoquímica; Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/genética; Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/metabolismo; Proteínas de Ciclo Celular; Secuenciación de Nucleótidos de Alto Rendimiento; Coactivador 2 del Receptor Nuclear/metabolismo

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Derrame Pleural / Neoplasias Óseas / Condrosarcoma Mesenquimal Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Cytopathology Asunto de la revista: PATOLOGIA Año: 2024 Tipo del documento: Article País de afiliación: China

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