Binding of the nuclear ribonucleoprotein family member FUS to RNA prevents R-loop RNA:DNA hybrid structures.

Thompson, Valery F; Wieland, Daniel R; Mendoza-Leon, Vivian; Janis, Helen I; Lay, Michelle A; Harrell, Lucas M; Schwartz, Jacob C

Thompson, Valery F; Wieland, Daniel R; Mendoza-Leon, Vivian; Janis, Helen I; Lay, Michelle A; Harrell, Lucas M; Schwartz, Jacob C.

Afiliación

Thompson VF; Department of Pharmacology, University of Arizona, Tucson, Arizona, USA; University of Arizona Cancer Center, Tucson, Arizona, USA.
Wieland DR; Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Mendoza-Leon V; Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Janis HI; Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Lay MA; Department of Pharmacology, University of Arizona, Tucson, Arizona, USA; University of Arizona Cancer Center, Tucson, Arizona, USA; Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Harrell LM; Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, USA.
Schwartz JC; Department of Pharmacology, University of Arizona, Tucson, Arizona, USA; University of Arizona Cancer Center, Tucson, Arizona, USA. Electronic address: jcschwartz@arizona.edu.

J Biol Chem ; 299(10): 105237, 2023 Oct.

Article en En | MEDLINE | ID: mdl-37690693

Asunto(s)

ADN; Estructuras R-Loop; Proteína FUS de Unión a ARN; ARN; ADN/metabolismo; Estructuras R-Loop/genética; ARN/metabolismo; Proteína FUS de Unión a ARN/metabolismo; Unión Proteica; Humanos; ARN Polimerasas Dirigidas por ADN/metabolismo; Células HEK293

Palabras clave

FET protein; FUS; R-loop; RNA; RNA polymerase; RNA-binding; RNA:DNA hybrid; TLS; fused in sarcoma; transcription

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: ADN / ARN / Proteína FUS de Unión a ARN / Estructuras R-Loop Límite: Humans Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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