The N6-methyladenosine demethylase FTO is required for odontoblast differentiation in vitro and dentine formation in mice by promoting RUNX2 exon 5 inclusion through RBM4.

Xu, Mi; Li, Bingrong; Huang, Junjun; Jia, Rong; Guo, Jihua

Xu, Mi; Li, Bingrong; Huang, Junjun; Jia, Rong; Guo, Jihua.

Afiliación

Xu M; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Li B; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Huang J; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Jia R; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Guo J; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

Int Endod J ; 56(12): 1534-1549, 2023 Dec.

Article en En | MEDLINE | ID: mdl-37698901

Asunto(s)

Subunidad alfa 1 del Factor de Unión al Sitio Principal; Odontoblastos; Animales; Humanos; Masculino; Ratones; Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/genética; Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/metabolismo; Diferenciación Celular; Subunidad alfa 1 del Factor de Unión al Sitio Principal/genética; Subunidad alfa 1 del Factor de Unión al Sitio Principal/metabolismo; Pulpa Dental; Dentina/metabolismo; Exones/genética; Ratones Endogámicos C57BL; ARN Mensajero/metabolismo; Proteínas de Unión al ARN/genética; Proteínas de Unión al ARN/metabolismo; Microtomografía por Rayos X

Palabras clave

animal model; cell differentiation; dental pulp stem cell(s); dentine; mRNA decay; odontoblast(s)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Subunidad alfa 1 del Factor de Unión al Sitio Principal / Odontoblastos Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Int Endod J Año: 2023 Tipo del documento: Article País de afiliación: China

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