Discordant skeletal muscle gene and protein responses to exercise.
Trends Biochem Sci
; 48(11): 927-936, 2023 11.
Article
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| MEDLINE
| ID: mdl-37709636
ABSTRACT
The ability of skeletal muscle to adapt to repeated contractile stimuli is one of the most intriguing aspects of physiology. The molecular bases underpinning these adaptations involve increased protein activity and/or expression, mediated by an array of pre- and post-transcriptional processes, as well as translational and post-translational control. A longstanding dogma assumes a direct relationship between exercise-induced increases in mRNA levels and subsequent changes in the abundance of the proteins they encode. Drawing on the results of recent studies, we dissect and question the common assumption of a direct relationship between changes in the skeletal muscle transcriptome and proteome induced by repeated muscle contractions (e.g., exercise).
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Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ejercicio Físico
/
Músculo Esquelético
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2023
Tipo del documento:
Article