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Discordant skeletal muscle gene and protein responses to exercise.
Bishop, David J; Hoffman, Nolan J; Taylor, Dale F; Saner, Nicholas J; Lee, Matthew J-C; Hawley, John A.
Afiliación
  • Bishop DJ; Institute for Health and Sport (iHeS), Victoria University, Melbourne, Australia. Electronic address: David.Bishop@vu.edu.au.
  • Hoffman NJ; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
  • Taylor DF; Institute for Health and Sport (iHeS), Victoria University, Melbourne, Australia.
  • Saner NJ; Institute for Health and Sport (iHeS), Victoria University, Melbourne, Australia.
  • Lee MJ; Institute for Health and Sport (iHeS), Victoria University, Melbourne, Australia.
  • Hawley JA; Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Trends Biochem Sci ; 48(11): 927-936, 2023 11.
Article en En | MEDLINE | ID: mdl-37709636
ABSTRACT
The ability of skeletal muscle to adapt to repeated contractile stimuli is one of the most intriguing aspects of physiology. The molecular bases underpinning these adaptations involve increased protein activity and/or expression, mediated by an array of pre- and post-transcriptional processes, as well as translational and post-translational control. A longstanding dogma assumes a direct relationship between exercise-induced increases in mRNA levels and subsequent changes in the abundance of the proteins they encode. Drawing on the results of recent studies, we dissect and question the common assumption of a direct relationship between changes in the skeletal muscle transcriptome and proteome induced by repeated muscle contractions (e.g., exercise).
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ejercicio Físico / Músculo Esquelético Idioma: En Revista: Trends Biochem Sci Año: 2023 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ejercicio Físico / Músculo Esquelético Idioma: En Revista: Trends Biochem Sci Año: 2023 Tipo del documento: Article