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Phosphoinositide 3-kinase as a therapeutic target in angiogenic disease.
Wu, Wenyi; Xia, Xiaobo; Tang, Luosheng; Luo, Jing; Xiong, Siqi; Ma, Gaoen; Lei, Hetian.
Afiliación
  • Wu W; Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Ophthalmology, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address: wenyi_wu@csu.e
  • Xia X; Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Ophthalmology, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
  • Tang L; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Luo J; Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Xiong S; Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China; Hunan Key Laboratory of Ophthalmology, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
  • Ma G; Department of Ophthalmology, The First Affiliated Hospital of Hainan Medical University, Haikou, 571199, China. Electronic address: 15757826611@163.com.
  • Lei H; Shenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, China. Electronic address: leithetian18@hotmail.com.
Exp Eye Res ; 236: 109646, 2023 11.
Article en En | MEDLINE | ID: mdl-37716399
ABSTRACT
Phosphoinositide 3-kinases (PI3Ks) generate lipids that control multitudinous intracellular cell signaling events which participate in cell survival and proliferation. In addition, PI3K signaling also contributes to metabolism, immunity, angiogenesis and cardiovascular homeostasis, and many diseases. The diverse actions of PI3K stem from the existence of their various isoforms and a variety of protein effectors. Hence, PI3K isoform-specific inhibitors have already achieved a wonderful effect on treating cancer. Herein, we summarize the molecular mechanism of PI3K inhibitors in preventing the permeability of vessels and neovascularization. Additionally, we briefly illustrate how PI3K signaling modulates blood vessel growth and discuss the different roles that PI3K isoforms play in angiogenesis.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas / Fosfatidilinositol 3-Quinasa Idioma: En Revista: Exp Eye Res Año: 2023 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fosfatidilinositol 3-Quinasas / Fosfatidilinositol 3-Quinasa Idioma: En Revista: Exp Eye Res Año: 2023 Tipo del documento: Article