Your browser doesn't support javascript.
loading
Host genetic variation at a locus near CHD1L impacts HIV sequence diversity in a South African population.
Schulz, Vanessa E; Tuff, Jeffrey F; Tough, Riley H; Lewis, Lara; Chimukangara, Benjamin; Garrett, Nigel; Abdool Karim, Quarraisha; Abdool Karim, Salim S; McKinnon, Lyle R; Kharsany, Ayesha B M; McLaren, Paul J.
Afiliación
  • Schulz VE; Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg, Manitoba, Canada.
  • Tuff JF; Sexually Transmitted and Bloodborne Infections Division, JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratories, Public Health Agency of Canada , Winnipeg, Manitoba, Canada.
  • Tough RH; Sexually Transmitted and Bloodborne Infections Division, JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratories, Public Health Agency of Canada , Winnipeg, Manitoba, Canada.
  • Lewis L; Department of Medical Microbiology and Infectious Diseases, University of Manitoba , Winnipeg, Manitoba, Canada.
  • Chimukangara B; Sexually Transmitted and Bloodborne Infections Division, JC Wilt Infectious Diseases Research Centre, National Microbiology Laboratories, Public Health Agency of Canada , Winnipeg, Manitoba, Canada.
  • Garrett N; Centre for the AIDS Programme of Research in South Africa , Durban, South Africa.
  • Abdool Karim Q; Centre for the AIDS Programme of Research in South Africa , Durban, South Africa.
  • Abdool Karim SS; Critical Care Medicine Department, NIH Clinical Center, National Institutes of Health , Bethesda, Maryland, USA.
  • McKinnon LR; Department of Virology, University of KwaZulu-Natal , Durban, South Africa.
  • Kharsany ABM; Centre for the AIDS Programme of Research in South Africa , Durban, South Africa.
  • McLaren PJ; Department of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal , Durban, South Africa.
J Virol ; 97(10): e0095423, 2023 10 31.
Article en En | MEDLINE | ID: mdl-37747237
IMPORTANCE: It has been previously shown that genetic variants near CHD1L on chromosome 1 are associated with reduced HIV VL in African populations. However, the impact of these variants on viral diversity and how they restrict viral replication are unknown. We report on a regional association analysis in a South African population and show evidence of selective pressure by variants near CHD1L on HIV RT and gag. Our findings provide further insight into how genetic variability at this locus contributes to host control of HIV in a South African population.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Variación Genética / Infecciones por VIH / VIH-1 / ADN Helicasas / Proteínas de Unión al ADN / Sitios Genéticos Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: J Virol Año: 2023 Tipo del documento: Article País de afiliación: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Variación Genética / Infecciones por VIH / VIH-1 / ADN Helicasas / Proteínas de Unión al ADN / Sitios Genéticos Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: J Virol Año: 2023 Tipo del documento: Article País de afiliación: Canadá