Characterization of N-Terminal Asparagine Deamidation and Clipping of a Monoclonal Antibody.

Zhen, Jing; Lee, Jennifer; Wang, Yueyang; McLaughlin, Lena; Yang, Fei; Li, Zhengjian; Wang, Jihong

Zhen, Jing; Lee, Jennifer; Wang, Yueyang; McLaughlin, Lena; Yang, Fei; Li, Zhengjian; Wang, Jihong.

Afiliación

Zhen J; Department of Analytical Sciences, U.S. Technical & Biologics Development, Horizon Therapeutics, Rockville, MD 20850, USA.
Lee J; Department of Analytical Sciences, U.S. Technical & Biologics Development, Horizon Therapeutics, Rockville, MD 20850, USA.
Wang Y; Department of Analytical Sciences, U.S. Technical & Biologics Development, Horizon Therapeutics, Rockville, MD 20850, USA.
McLaughlin L; Department of Analytical Sciences, U.S. Technical & Biologics Development, Horizon Therapeutics, Rockville, MD 20850, USA.
Yang F; Department of Analytical Sciences, U.S. Technical & Biologics Development, Horizon Therapeutics, Rockville, MD 20850, USA.
Li Z; Department of Analytical Sciences, U.S. Technical & Biologics Development, Horizon Therapeutics, Rockville, MD 20850, USA.
Wang J; Department of Analytical Sciences, U.S. Technical & Biologics Development, Horizon Therapeutics, Rockville, MD 20850, USA.

Antibodies (Basel) ; 12(3)2023 Sep 19.

Article en En | MEDLINE | ID: mdl-37753973

Palabras clave

N-terminal truncation; biopharmaceutical characterization; charge profile; deamidation; liquid chromatographymass spectrometry (LC-MS); monoclonal antibody(s)

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Antibodies (Basel) Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google