FBXW10: a male-biased E3 ligase in liver cancer.

Sahay, Osheen; Barik, Ganesh Kumar; Islam, Sehbanul

Sahay, Osheen; Barik, Ganesh Kumar; Islam, Sehbanul.

Afiliación

Sahay O; Cancer Biology Division, National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind Road, Pune, Maharashtra 411007, India. Electronic address: osheen.mhg.bhu13@gmail.com.
Barik GK; Cancer Biology Division, National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind Road, Pune, Maharashtra 411007, India.
Islam S; Department of Cancer Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Biomedical Research Building II/III, 421 Curie Boulevard, Philadelphia, PA 19104, USA. Electronic address: sehbanul.islam@pennmedicine.upenn.edu.

Trends Cancer ; 9(11): 876-878, 2023 11.

Article en En | MEDLINE | ID: mdl-37775405

ABSTRACT

ABSTRACT

Two recent studies, by Lin et al. and Liu et al., unveiled the pivotal role of F-box and WD repeat domain containing 10 (FBXW10)-mediated ubiquitination and activation of oncogenic signaling as the primary driver behind the higher prevalence of hepatocellular carcinoma (HCC) in men. These discoveries shed light on underlying mechanisms of sex-biased cancer and provide a promising roadmap for both basic and clinical research.

Asunto(s)

Carcinoma Hepatocelular; Proteínas F-Box; Neoplasias Hepáticas; Humanos; Masculino; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patología; Ubiquitina-Proteína Ligasas/genética; Ubiquitina-Proteína Ligasas/metabolismo; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/patología; Proteínas F-Box/genética; Proteínas F-Box/metabolismo; Ubiquitinación

Palabras clave

FBXW10, signaling pathway; hepatocellular carcinoma; precision medicine; sex bias; ubiquitination

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Proteínas F-Box / Neoplasias Hepáticas Tipo de estudio: Risk_factors_studies Límite: Humans / Male Idioma: En Revista: Trends Cancer Año: 2023 Tipo del documento: Article

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