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HER-2-Targeted Boron Neutron Capture Therapy with Carborane-integrated Immunoliposomes Prepared via an Exchanging Reaction.
Kawasaki, Riku; Oshige, Ayano; Yamana, Keita; Hirano, Hidetoshi; Nishimura, Kotaro; Miura, Yamato; Yorioka, Ryuji; Sanada, Yu; Bando, Kaori; Tabata, Anri; Yasuhara, Kazuma; Miyazaki, Yusuke; Shinoda, Wataru; Nishimura, Tomoki; Azuma, Hideki; Takata, Takushi; Sakurai, Yoshinori; Tanaka, Hiroki; Suzuki, Minoru; Nagasaki, Takeshi; Ikeda, Atsushi.
Afiliación
  • Kawasaki R; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, 739-8527, Japan.
  • Oshige A; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, 739-8527, Japan.
  • Yamana K; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, 739-8527, Japan.
  • Hirano H; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, 739-8527, Japan.
  • Nishimura K; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, 739-8527, Japan.
  • Miura Y; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, 739-8527, Japan.
  • Yorioka R; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, 739-8527, Japan.
  • Sanada Y; Institute for Integrated Radiation and Nuclear Science, Kyoto University Asashiro-Nishi, Kumatori-cho, Sennan-gun, Osaka, 590-0494, Japan.
  • Bando K; Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka city, 558-8585, Japan.
  • Tabata A; Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka city, 558-8585, Japan.
  • Yasuhara K; Division of Materials Science, Graduate School of Science and Technology and Center for Digital Green-Innovation, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma, Nara, 630-0192, Japan.
  • Miyazaki Y; Research Institute for Interdisciplinary Science, Okayama University, 3-1-1 Tsushuma-naka, Kita-ku, Okayama, 700-8530, Japan.
  • Shinoda W; Research Institute for Interdisciplinary Science, Okayama University, 3-1-1 Tsushuma-naka, Kita-ku, Okayama, 700-8530, Japan.
  • Nishimura T; Department of Chemistry and Materials, Faculty of Textile Science and Technology, Shinshu University, Ueda, 386-8567, Japan.
  • Azuma H; Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka city, 558-8585, Japan.
  • Takata T; Institute for Integrated Radiation and Nuclear Science, Kyoto University Asashiro-Nishi, Kumatori-cho, Sennan-gun, Osaka, 590-0494, Japan.
  • Sakurai Y; Institute for Integrated Radiation and Nuclear Science, Kyoto University Asashiro-Nishi, Kumatori-cho, Sennan-gun, Osaka, 590-0494, Japan.
  • Tanaka H; Institute for Integrated Radiation and Nuclear Science, Kyoto University Asashiro-Nishi, Kumatori-cho, Sennan-gun, Osaka, 590-0494, Japan.
  • Suzuki M; Institute for Integrated Radiation and Nuclear Science, Kyoto University Asashiro-Nishi, Kumatori-cho, Sennan-gun, Osaka, 590-0494, Japan.
  • Nagasaki T; Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka Metropolitan University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka city, 558-8585, Japan.
  • Ikeda A; Program of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, 739-8527, Japan.
Chemistry ; 29(72): e202302486, 2023 Dec 22.
Article en En | MEDLINE | ID: mdl-37792507
ABSTRACT
Boron neutron capture therapy (BNCT) is a promising modality for cancer treatment because of its minimal invasiveness. To maximize the therapeutic benefits of BNCT, the development of efficient platforms for the delivery of boron agents is indispensable. Here, carborane-integrated immunoliposomes were prepared via an exchanging reaction to achieve HER-2-targeted BNCT. The conjugation of an anti-HER-2 antibody to carborane-integrated liposomes successfully endowed these liposomes with targeting properties toward HER-2-overexpressing human ovarian cancer cells (SK-OV3); the resulting BNCT activity toward SK-OV3 cells obtained using the current immunoliposomal system was 14-fold that of the l-BPA/fructose complex, which is a clinically available boron agent. Moreover, the growth of spheroids treated with this system followed by thermal neutron irradiation was significantly suppressed compared with treatment with the l-BPA/fructose complex.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Boranos / Terapia por Captura de Neutrón de Boro Límite: Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Boranos / Terapia por Captura de Neutrón de Boro Límite: Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2023 Tipo del documento: Article País de afiliación: Japón