Adult height improved over decades in patients with X-linked hypophosphatemia: a cohort study.
Eur J Endocrinol
; 189(4): 469-475, 2023 Oct 17.
Article
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| MEDLINE
| ID: mdl-37831782
ABSTRACT
OBJECTIVES:
The aim of this study is to analyze height after cessation of growth (final height [FH]) and its evolution over the last decades in X-linked hypophosphatemia (XLH) patients in France, as the data on natural history of FH in XLH are lacking.DESIGN:
We performed a retrospective observational study in a large cohort of French XLH patients with available data on FH measurements. MATERIALS ANDMETHODS:
We divided patients into 3 groups according to their birth year group 1 born between 1950 and 1974, group 2 born between 1975 and 2000, and group 3 born between 2001 and 2006, respectively, and compared their FHs.RESULTS:
A total of 398 patients were included. Mean FHs were the following for group 1, -2.31 ± 1.11 standard deviation score (SDS) (n = 127), 156.3 ± 9.7â cm in men and 148.6 ± 6.5â cm in women; for group 2, -1.63 ± 1.13 SDS (n = 193), 161.6 ± 8.5â cm in men and 153.1 ± 7.2â cm in women; and for group 3, -1.34 ± 0.87 SDS (n = 78), 165.1 ± 5.5â cm in men and 154.7 ± 6â cm in women. We report a significant increase in mean FH SDS over 3 generations of patients, for both men and women (P < .001). Final height SDS in male (-2.08 ± 1.18) was lower than in female (-1.70 ± 1.12) (P = .002).CONCLUSION:
The FH of XLH patients in France increased significantly over the last decades. Even though men's FHs improved more than women's, men with XLH remain shorter reflecting a more severe disease phenotype. While the results are promising, most patients with XLH remain short leaving room for improvement.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hipofosfatemia
/
Raquitismo Hipofosfatémico Familiar
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Eur J Endocrinol
Asunto de la revista:
ENDOCRINOLOGIA
Año:
2023
Tipo del documento:
Article
País de afiliación:
Bélgica