MicroRNA regulators of vascular pathophysiology in chronic kidney disease.
Clin Chim Acta
; 551: 117610, 2023 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-37863246
ABSTRACT
Coronary artery disease (CAD) is a severe comorbidity in chronic kidney disease (CKD) due to heavy calcification in the medial layer and inflamed plaques. Chronic inflammation, endothelial dysfunction and vascular calcification are major contributors that lead to artherosclerosis in CKD. The lack of specific symptoms and signs of CAD and decreased accuracy of noninvasive diagnostic tools result in delayed diagnosis leading to increased mortality. MicroRNAs (miRNAs) are post-transcriptional regulators present in various biofluids throughout the body. In the circulation, miRNAs have been reported to be encapsulated in extracellular vesicles and serve as stable messengers for crosstalk among cells. miRNAs are involved in pathophysiologic mechanisms including CAD and can potentially be extended from basic research to clinical translational practice.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de la Arteria Coronaria
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MicroARNs
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Insuficiencia Renal Crónica
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Placa Aterosclerótica
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Calcificación Vascular
Límite:
Humans
Idioma:
En
Revista:
Clin Chim Acta
Año:
2023
Tipo del documento:
Article