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Zebrafish TMEM47 is an effective blocker of IFN production during RNA and DNA virus infection.
Lu, Long-Feng; Li, Zhuo-Cong; Zhang, Can; Chen, Dan-Dan; Han, Ke-Jia; Zhou, Xiao-Yu; Wang, Xue-Li; Li, Xi-Yin; Zhou, Li; Li, Shun.
Afiliación
  • Lu L-F; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.
  • Li Z-C; University of Chinese Academy of Sciences , Beijing, China.
  • Zhang C; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.
  • Chen D-D; University of Chinese Academy of Sciences , Beijing, China.
  • Han K-J; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.
  • Zhou X-Y; University of Chinese Academy of Sciences , Beijing, China.
  • Wang X-L; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.
  • Li X-Y; University of Chinese Academy of Sciences , Beijing, China.
  • Zhou L; Institute of Hydrobiology, Chinese Academy of Sciences , Wuhan, China.
  • Li S; College of Fisheries and Life Science, Dalian Ocean University , Dalian, China.
J Virol ; 97(11): e0143423, 2023 Nov 30.
Article en En | MEDLINE | ID: mdl-37882518
ABSTRACT
IMPORTANCE Mitochondrial antiviral signaling protein (MAVS) and stimulator of interferon (IFN) genes (STING) are key adaptor proteins required for innate immune responses to RNA and DNA virus infection. Here, we show that zebrafish transmembrane protein 47 (TMEM47) plays a critical role in regulating MAVS- and STING-triggered IFN production in a negative feedback manner. TMEM47 interacted with MAVS and STING for autophagic degradation, and ATG5 was essential for this process. These findings suggest the inhibitory function of TMEM47 on MAVS- and STING-mediated signaling responses during RNA and DNA virus infection.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Virus ARN / Pez Cebra / Interferones / Proteínas de Pez Cebra / Infecciones por Virus ADN / Inmunidad Innata Límite: Animals Idioma: En Revista: J Virol Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Infecciones por Virus ARN / Pez Cebra / Interferones / Proteínas de Pez Cebra / Infecciones por Virus ADN / Inmunidad Innata Límite: Animals Idioma: En Revista: J Virol Año: 2023 Tipo del documento: Article País de afiliación: China