Zebrafish TMEM47 is an effective blocker of IFN production during RNA and DNA virus infection.
J Virol
; 97(11): e0143423, 2023 Nov 30.
Article
en En
| MEDLINE
| ID: mdl-37882518
ABSTRACT
IMPORTANCE Mitochondrial antiviral signaling protein (MAVS) and stimulator of interferon (IFN) genes (STING) are key adaptor proteins required for innate immune responses to RNA and DNA virus infection. Here, we show that zebrafish transmembrane protein 47 (TMEM47) plays a critical role in regulating MAVS- and STING-triggered IFN production in a negative feedback manner. TMEM47 interacted with MAVS and STING for autophagic degradation, and ATG5 was essential for this process. These findings suggest the inhibitory function of TMEM47 on MAVS- and STING-mediated signaling responses during RNA and DNA virus infection.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Infecciones por Virus ARN
/
Pez Cebra
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Interferones
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Proteínas de Pez Cebra
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Infecciones por Virus ADN
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Inmunidad Innata
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
2023
Tipo del documento:
Article
País de afiliación:
China