Total Synthesis of the Proposed Structure of Neaumycin B.
Angew Chem Int Ed Engl
; 62(51): e202313186, 2023 Dec 18.
Article
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| ID: mdl-37889502
ABSTRACT
The total synthesis of the proposed structure of anti-glioblastoma natural product neaumycin B was achieved in 22 steps (longest linear sequence). The synthesis features HCl-mediated [6,6]-spiroketalization, a combination of Krische iridium-catalyzed crotylation, Marshall palladium-catalyzed propargylation, Fürstner nickel-catalyzed regio- and enantioselective vicinal monoprotected diol formation, Brown crotylation and asymmetric halide-aldehyde cycloaddition, so as to establish the challenging contiguous stereocenters.
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01-internacional
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MEDLINE
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Angew Chem Int Ed Engl
Año:
2023
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Article