A conserved core region of the scaffold NEMO is essential for signal-induced conformational change and liquid-liquid phase separation.

DiRusso, Christopher J; DeMaria, Anthony M; Wong, Judy; Wang, Wei; Jordanides, Jack J; Whitty, Adrian; Allen, Karen N; Gilmore, Thomas D

DiRusso, Christopher J; DeMaria, Anthony M; Wong, Judy; Wang, Wei; Jordanides, Jack J; Whitty, Adrian; Allen, Karen N; Gilmore, Thomas D.

Afiliación

DiRusso CJ; Department of Biology, Boston University, Boston, Massachusetts, USA.
DeMaria AM; Department of Chemistry, Boston University, Boston, Massachusetts, USA.
Wong J; Department of Biology, Boston University, Boston, Massachusetts, USA.
Wang W; Department of Biology, Boston University, Boston, Massachusetts, USA.
Jordanides JJ; Department of Chemistry, Boston University, Boston, Massachusetts, USA.
Whitty A; Department of Chemistry, Boston University, Boston, Massachusetts, USA.
Allen KN; Department of Chemistry, Boston University, Boston, Massachusetts, USA. Electronic address: drkallen@bu.edu.
Gilmore TD; Department of Biology, Boston University, Boston, Massachusetts, USA. Electronic address: gilmore@bu.edu.

J Biol Chem ; 299(12): 105396, 2023 Dec.

Article en En | MEDLINE | ID: mdl-37890781

Asunto(s)

Quinasa I-kappa B; Quinasa I-kappa B/química; Quinasa I-kappa B/metabolismo; FN-kappa B/metabolismo; Separación de Fases; Transducción de Señal; Ubiquitina/metabolismo; Humanos

Palabras clave

IKK; NEMO; NF-kappaB; conformational change; liquid-liquid phase separation; mutant; optineurin; scaffold protein; signal transduction

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Quinasa I-kappa B Límite: Humans Idioma: En Revista: J Biol Chem Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos

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